6a-Fluoroprednisolone

Microbiological oxidation has proven of enormous value in steroid chemistry, often affording selective means of functionalizing remote and chemically inactivated positions. It will bear mentioning that the 11-oxygen for all commercially available corticoids is in fact introduced by such a reaction carried out on plant scale. Preparation of the 1-dehydro analogue of 207 involves biooxidation to introduce the 16-hydroxyl. Incubation of 6a-fluoroprednisolone... 

Names synonyms FLUOROHYDROCORTISONE fludrocortisone 9a-fluorohydrocortisone 9a-fluorocoriisol fluohydrisone 9a-fluoro-11 17a.21 -trihydroxy-4-pregnene- 3.20-d lone 9a-fluoro-17-hydroxycorticosterone. FLUOROMETHOLONE 9a-fluoro-l ip,l7a-dihydroxy-6a-methyl-1.4-prcgnadiene 3,20-dione 21 -desoxy-9a-fluoro-6 -methyl-prednisolone. FLUPREDNISOLONE 6a- fluoroprednisolone 6a-fluoro-1 -dehydrohydrocortisone 6a-fluoro-11 17a.21 -trihydroxy-1,4-pregnadienc-3.20-dione. 

Many synthetic corticoids were introduced following the discovery of triamcinolone. These include triamcinolone 16,17-acetonide, 6o -methylprednisolone, 16a -methyl-9o -fluoroprednisolone (dexamethasone), 16 -methyl-9a(-fluoroprednisolone (betamethasone), 6o -fluoro-16a-methylprednisolone (paramethasone), 16-methylene-prednisolone, and 6a, 9a -dlfluoro-16a-hydroxyprednisolone 16,17-acetonide (fluocino-lone acetonide). Microbiology played no essential role in their discovery, although in some cases microbiological technology has been employed to advantage in their manufacture. 

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