5HT3 receptor antagonists ondansetron

Ondansetron is one of a group of 5HT3-receptor antagonists currently available in the UK, which also includes granisetron, tropisetron, dolasetron and palonosetron. Dexamethasone is a corticosteroid. Ranitidine is a histamine-2 (H2)-receptor antagonist. 

One of the major side-effects of cytotoxic chemotherapy is nausea and vomiting. It is essential therefore to control this with prophylactic antiemetic therapy. A number of agents are currently available and are effective at controlling chemotherapy-induced emesis. The most potent of these are 5HT3-receptor antagonists that include ondansetron, granisetron and palonosetron. 

Managemeut of adverse drug reactious 5HT3 receptor antagonists The addition of ondansetron and ketorolac to fentanyl was associated with less nausea and vomiting and dizziness in 135 patients undergoing thyroid surgery [76 ]. 

Azasetron, a potent selective 5HT3 receptor antagonist, is a benzamide derivative that has a different chemical structure and a longer duration of action than other 5HT3 receptor antagonists, such as granisetron, ondansetron, and tropisetron [29 ]. For a comparison of azasetron with ondansetron, see above. 

Although other 5HT3 receptor antagonists (particularly ondansetron) have been previously reported to cause seizures, in this case the role of palonosetron was uncertain. 

Ondansetron, granisetron, topisetron, and batanopride are antagonists of the 5HT3 receptor, and are considered effective in controlling cancer-chemotherapy-induced emesis. Clozapine, an effective antipsychotic agent (neuroleptics) with little or no extrapyramidal... 

HT3 (a serotonin receptor—see the following section) antagonists ondansetron, granisetron... 

Ondansetron is a 5HT3 antagonist, blocking serotonin receptors in the central nervous system and the gastrointestinal tract. It is useful in the management of postoperative nausea and vomiting associated with cytotoxics. 

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