3H-1,4-Benzodiazepines

Chemical Name 2/3-N-Diethvlaminoethylthio-4-p-phenylthiophenyl-3H-1,5-benzodiazepine iodomethylate... 

H- 1,5-Benzodiazepines 14 are formed from benzene-1,2-diamines and l,3-diphenylprop-2-yn-l-one.265... 

The action of the same reagents on benzodiazepines with unsubstituted amino groups (99 and 101) generates hydroxy derivatives 100, or is accompanied by dehydration (benzodiazepine 102, Scheme 4.33). 3H- 1,5-Benzodiazepine 104 can be obtained with satisfactory yields using a milder oxidant, e.g., K2S205 [105]. 

Although this methodology is widely applicable for the preparation of many 1,1-enediamines, 2-(aroylmethylene)benzimidazolines (29) cannot be obtained from the reaction of benzoyl-substituted ketene dithioacetals 30 and o-phenylenediamine. Instead of 29, 3H- 1,5-benzodiazepines 31 are isolated from the reaction64. Similar results have been reported for the reaction of 30 and other primary aromatic diamines70,71. A recent study64 has revealed that an enamine-imine tautomeric equilibrium is involved in the reaction process (Scheme 2). This equilibrium between 33A and 33B is affected by the... 

Willy B, Dallos T, Rominger F et al (2008) Three-component synthesis of cryofluorescent 2, 4-disubstituted 3H-1, 5-benzodiazepines-conformational control of emission properties. Eur J Org Chem 2008 4796-4805... 

SYNS CHLOREPIN CLOBAZAM CLOREPIN FRISIUM H-4723 HR 376 LM-2717 l-PHENYL-5-METHYL-8-CHLORO-l,2,4,5-TETRAHYDRO-2,4-DIOXO-3H-1,5-BENZODIAZEPINE RU-4723 URBANYL... 

Tibezonium Iodide. N,N-Diethyi-N-melhyl-2-[[4-[4-(phenylthio)phenyl]-3 H-I, S-benzodiazepin-2-yt thio -ethanaminium iodide diethy]methyl[2-[[4-[p-(phenylthio)-phenyl]-3H-l,5-benzodiazepin-2-yl]thio]ethy]]ammonium iodide 2-[d-(M-diethylamino)ethylthio]-4-(p-phenylthio)-phenyl-3H-1,5-benzodiazepine methiodide thiabenzazon-ium iodide Rec-15/0691 Amoral. CaH N,S2 mol wt 601.6], C 55.90%, H 5.36%, ] 21.09%, N 6.98%, S 10.66%, l,5-Benzodiazepine deny with bactericidal activity. Prepn D. Nardi et al, Swiss pat. 555,347 (1974 to Recordati). C.4 82, 434S0 (1975). Synthesis, physical characteristics, antibacterial activity eidem, Experieittia 31, 440 (1975) eidem. Farmaco Ed. Sci. 30, 248 (1975). Structure activity study C. Greico et al. ibid. 32, 909 (1977). Antimicrobial activity M. Veronese et al. Chemotherapy 23, 90 (1977). 

This treatment is continued until the j3-diethylaminoethyl chloride disappears (TLC). The oil is then dissolved in isopropanol and weakly acidified w h HCI in propanol. The 2j3-N-diethyl-aminoethylthio-4-p-phenylthiophenyl-3H-1,5-benzodiazepine HCI product crystallizes by addition of anhydrous ethyl ether to the solution. The crystals are filtered and recrystallized from ethyl acetate. Yield 3.65 g, melting point 150°C. 

Chemical Name 2j3-N-Diethvlaminoethylthio-4-p-phenvlthiophenyl-3H-1,5-benzodiazepine lodomethylate... 

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