17a-Acetoxy-progesterone

Dehydro-17a-acetoxy-progesterone Succinimide, N-chloro-Perchloric acid Aluminum oxide... 

For further confirmation of this observation 10 breast carcinoma patients whose premenstrual endometrium was hyperplastic were treated with a gestagen (17a-acetoxy-progesterone cyclopentyl enol ether) which at the oral dose of 20 mgr. daily for 10 days, induces a complete secretory transformation of the endometrium. 

Although chlorine azide and bromine azide tend to give some dihalogen adducts, these reagents have been used in the presence of alcohol, ester and epoxy functions without interference.In the case of 17a-acetoxy-A -progesterone, a selective addition to the 6,7-double bond is obtained. ... 

Mass Spectra.—A computer analysis of mass spectra of progesterone and twenty-nine of its stereoisomers and alkylated derivatives has established the main fragmentation pathways and their dependence on configurations, particularly at C-10 and C-17, and on the substitution pattern. Mass spectra of 17a-acetoxy-, Ha-hydroxy-, and 17a-methoxy-progesterones are dominated by fragmentations J. Dillon and K. Nakanishi, J. Amer. Chem. Soc., 1975,97, 5409, 5417. 

The second structural class of steroidal progestins consists of pregnane derivatives like medroxyprogesterone acetate (MPA) (9), megestrol acetate (10) or cyproterone acetate (11). The introduction of a 17a-acetoxy group and different substituents in the 6-position of the parent molecule progesterone leads to an increase in metabolic stability and to orally active compounds. Cyproterone acetate was the first progestin... 

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