SEARCH Articles Figures Tables Tyrosine residues are subject to nucleophilic and electrophilic reactions. The phenolate ion may be alkylated or acylated using a variety of bioconjugate reagents. Its aromatic ring also may undergo electrophilic addition using diazonium chemistry or Mannich condensation, or be halogenated with radioactive isotopes such as 125I. [Publishers Imprint] See Also: Tyrosine residues are subject to nucleophilic and electrophilic reactions. The phenolate ion may be alkylated or acylated using a variety of bioconjugate reagents. Its aromatic ring also may undergo electrophilic addition using diazonium chemistry or Mannich condensation, or be halogenated with radioactive isotopes such as 125I.