Lysosomes in receptor-mediated endocytosis via clathrin-coated pits. 1 Endo-cytotic vesicles fuse to form early endosomes. 2 Vesicle contents are sorted, and receptors, clathrin, and lipids are sent back to the plasma membrane. 3 Transport vesicles from the trans-Golgi carry lysosomal hydrolases to the late endosome. 4 Lysosomes containing concentrated hydrolases digest proteins and other components acquired from endocytotic vesicles.