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Discovery of pyridazine insecticides.

Discovery of rate acceleration by hydroxylic solvents

Discovery of spirodiclofen 7f and spiromesifen 8a.

Discovery of spirotetramat 32.

Discovery of substituted spirocyclic tetramic acid derivatives.

Discovery of the combined C-H insertion Cope rearrangement

Discovery of the hydroformylation by Otto Roelen.

Discovery of the Initial Lead Compound 3

Discovery of the Petasis borono-Mannich reaction using paraformaldehyde, amines and alkenylboronic acids.

Discovery of the Type K rearrangement

Discovery of tubacin and histacin—two selective deacetylation inhibitors.

Discovery of Urotensin II GPCR antagonist by peptide mimetic approaches. 3D models of the NMR solution structure of cyclic peptide derivatives were used as templates for virtual 3D pharmacophore searches and resulted into non-peptidic hits.

Discovery of vemurafenib from a generic kinase-active fragment.

Discovery process for cotton-based dressing containing fiber-protease inhibitors for application to chronic wounds where proteases such as elastase and metalloproteases are elevated.

Discovery route for 131.

Discovery route to crizotinib analogs.

Discovery route.

Discovery screening workflow for new polyolefin catalysts.

Discovery Strategy

Discovery success

Discovery synthesis of Almorexant involving a one-pot Ugi-3CR and Pictet-Spengler-2CR reaction.

Discovery synthesis of P2 domain of telaprevir.

Discovery synthesis of PI fragment of telaprevir.

Discovery synthesis via the intramolecular Heck route.

Discovery synthesis.



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