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Hypothetical model of striatal dopaminergic terminal in normal and DAT-deficient mice. Elimination of the DAT results in fivefold elevated extracellular levels of DA. Lack of inward transport in DAT-KO mice also results in 20-fold decreased intracellular DA stores. These low intracellular levels of DA are extremely sensitive to inhibition of DA synthesis, suggesting that they represent the newly synthesized DA pool. Note that synthesis rate is increased in DAT-KO mice, but cannot restore the deficiency in DA storage in DAT-KO mice levels of stored DA or whether all vesicles contain 5 of the normal content has not been formally tested and requires further investigations.

Hypothetical model of synthesis, storage, and release of ACh. Choline is also taken up into the neuron by a low-affinity uptake system and converted partly to phosphorylcholine.

Hypothetical model of the action of SNAP receptors

Hypothetical model of the interactions between CCK, via CCK and CCK2 receptors, and the opioid system via delta opioid and mu opioid receptors. CCK agonists, endogenous and or exogenous, stimulate the CCK2 and or the CCKi receptors, which can modulate the opioidergic systems either directly . In addition, activation of mu opioid receptors could negatively modulate the release of endogenous CCK, whereas delta opioid receptors may enhance it.

Hypothetical model of the interface between MAPP with hydroxyl groups of jute

Hypothetical model of the phytotoxic mechanism of action for herbicides that inhibit Protox. Protoporphyrinogen which accumulated as a result of Protox inhibition leaves the membrane-bound, channeled porphyrin pathway and is autooxidized to PPIX. Redrawn from .

Hypothetical model of the pore structure in carbon membranes.

Hypothetical model of the PR-la promoter. The numbers under the drawing indicate base pairs relative to the start site of transcription.

Hypothetical model of the regulation of glutamate NMDA receptor channels by non-esterified arachidonate in neurons.

Hypothetical model showing how a conformational rearrangement of the transmembrane helices may simultaneously change the accessibility of the cation binding site from one side of the membrane to the other and reduce the affinity of the binding site. The open circles represent protein ligands that constitute the binding site. The closed circles represent the ion. Modified from Tanford, 1982a.

Hypothetical model showing the modulation of glutamate transporter by arachidonic acid. Interactions of glutamate with its receptor result in depolarization and Ca2 entry into the cell. Ca2 -mediated stimulation of PLA2 results in breakdown of neural membrane phospholipids and the release of arachidonic acid. Arachidonic acid not only modulates proton conductance associated with neuronal excitability, but also provides eicosanoids, which may control the glutamate transporter

Hypothetical models for the binding of ozone to Cu-centers appropriate for the two-electron reduction of ozone to water and oxygen. See the text for a description

Hypothetical models of interaction between substrate or inhibitor with the active site

Hypothetical models utilizing the clasp configuration proposed by Koshland. el at, Pentameric IgM

Hypothetical modes of initiation of .

Hypothetical molecular formula of an asphaltene molecule constructed from HNMR analysis of the Lagunillas oil asphaltene .

Hypothetical molecular structures in polyalkenoate cements, where A represents OH- or F-.

Hypothetical molecular weight distribution plot showing number and weight average molecular weights.

Hypothetical molecule with nuclei , J and electrons, ij and interparticle separations as shown.

Hypothetical molecule with nuclei , J and two elections, 1, 2, and interparticle separations as shown.

Hypothetical molecule with nuclei , J and two electrons, 1, 2, and interparticle separations as shown.

Hypothetical molecule with nuclei I, J and elections, i, j and interparticle separations as

Hypothetical molecule with nuclei I, J and electrons, i, j and inteiparticle separations as

Hypothetical molecules to illustrate the energetic terms included in Eqs. to dimmish the influence of these external interactions on geometries, vibrations, and conformational energetics. It should also be noted that additional atoms that could be present in molecule A would represent 1,5 interactions, 1,6 interactions, and so on, and would also interact with each other via the external terms.

Hypothetical movement of an acyl chain between a KS and the upstream ACP. Once the acyl-KS is formed, the acyl moiety can potentially be removed by de-acylation by the downstream ACP and subsequent hydrolysis by an acyl hydrolase. Alternatively, direct hydrolysis from the KS active site can occur



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