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G-6 Reactive trajectoiy.

G-6 shows schematically the position of the molecules at the start and the end of idle calculation. Figure G-7 shows another trajectoiy calculation however, this trajectoiy results in a reaction. We see from the figure that at a value

G-7 Distances of separation as a function of time for a reactive trajectory. Courtesy of K. J. Laidler, Chemical Kinetics, 3rd ed., HarperCollins, New York,

G-8 Reaction probability as a function of the impact parameter. Courtesy oif K. J. Laidler, ChemicalKinetics, 3rd ed., HarperCollins, New York, 1987.Redrawn fromM. Karplus, R. N, Porter, andR. D. Sherma,X Chem.Phys., 43.

G-8 shows the reaction probability as a function of the impact parameter for a particular t when B—C is in the groimd state .

G-9 Reaction cross section as a function of relative velocity for 7 0,

G-Banded chromosome preparation from dCF cell line with a 200-fold increase in ADA activity. Arrow marks an HSR.

G-bandei karyotype at a 400 band resolution showing the R bands identified by Saccone et al. ,

G-BB storage stability—percent mass on backup section vs. time data points, average of two determinations

G-BB storage stability—percent total mass retained vs. time data points, average of two determinations

G-E data for the model, with the calculated G-E data for the prototype

G-factors of ozone production as a function of reduced eleetrie field E o in room-temperature atmospherie-pressure discharges in air and

G-L and L-L reactor hydrodynamics not known well.

G-l Some preparations and reactions of rhodium compounds.

G-loops form in transcribed G-rich regions. Diagram of G-loop, showing the RNAjDNA hybrid on the template strand and G4 DNA interspersed with single-stranded regions on the G-rich strand

G-mode frequency of SWNTs as a function of pump-probe time delay obtained from transient transmission measurement using a sub-10 fe pulse at 2.1 eV. From

G-P section through

G-protein activation cycle. In the resting cell, G-protein exists as a trimer of a, 3, and y subunits with GDP bound to the a subunit. Activated ligand-receptor complexes for activation of small GTP-binding proteins. Free a-GDP binds 37 subunits, terminating their activity and completing the cycle.

G-protein catalytic cycle.

G-protein catalytic cycle. Debinding of GDP and binding of GTP follows interaction of the inactive complex with the ligand stimulated receptor . The active G .GTP complex and the complex are able to activate effectors, which include both enzymes and ion channels. Deactivation occurs as a consequence of a slow intrinsic GTPase activity manifest by G leading to G .GDP which recombines with Gp., to give the inactive G g. GDP heterotrimeric complex.

G-protein coupled receptor Arrestins can also act as scaffold proteins that bring together members of the MAP kinase pathway and so activate MAP kinase signaling.

G-protein coupled receptor Arrestins can also act as scaffold proteins tliat bring togetlier members of tlie MAP kinase patliway and so activate MAP kinase signaling.

G-protein Coupled Receptors

G-protein cycle. Adapted from R. D. Vale, J. Cell Biol. 135,291 .

G-protein-coupled receptors are linked to several second messenger . The most important in psychopharmacology are the adenylate cyclase and phospholipid hydrolysis mechanisms.



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