Zolpidem Valproate

Valproate appears to increase the serum levels of diazepam lo-razepam and possibly midazolam, while clobazam appears to raise valproate levels. Clonazepam clearance may increase and valproate clearance decrease during concurrent use, and increased adverse effects have been seen. An isolated case describes sleepwalking in a patient taking valproate and zolpidem. 

A report describes sleepwalking in a patient when valproate 250 mg twice daily was added to treatment with zolpidem 5 mg at night and citalopram 30 mg daily. The patient stopped the valproate and the sleepwalking episodes resolved. Later, the valproate was restarted causing the sleepwalking to recur. This time the symptoms resolved when the zolpidem was stopped. ... 

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See also in sourсe #XX -- [ ]

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