Zinc-induced tubulin sheets crystallography

Figure 7-33 Stereoscopic ribbon diagram of the tubulin dimer with a-tubulin with bound GTP at the top and P-tubulin with bound GDP at the bottom. The p-tubulin subunit also contains a bound molecule of taxotere (see Box 7-D) which is labeled TAX. This model is based upon electron crystallography of zinc-induced tubulin sheets at 0.37-nm resolution and is thought to approximate closely the packing of the tubulin monomers in microtubules.315 The arrow at the left points toward the plus end of the microtubule. Courtesy of Kenneth H. Downing.

Based on the structure of ap-tubulin dimer, resolved by electron crystallography of zinc-induced tubulin sheets, a previously unrecognised... 

The atomic structure of tubulin protofilaments (Figs. 3 and 4) is known from 3.5 A resolution maps, the first of which came from electron crystallography of zinc-induced 2D sheets (Nogales et al., 1998b), subsequently refined (Lowe et al., 2001). Recent data, including important information... 

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