Zaleplon Rifampin

Drugs that induce CYP3A4 CYP3A4 is a minor metabolizing enzyme of zaleplon. The CYP3A4-inducer rifampin reduced zaleplon C ax AUC by approximately... 

Zaleplon (Sonata) [C IV] [Sedotive/Hypnotic] Uses Insomnia Action A nonbenzodiazepine sedative/hypnotic, a pyrazolopyrimidine Dose 5-20 mg hs PRN -1- w/ renal/hepatic insuff, elderly Caution [C, /-] w/ mental/ psychological conditions Contra Component allergy Disp Caps SE HA, edema, amnesia, somnolence, photosens Interactions t CNS depression W/ CNS d es-sants, imipramine, thioridazine, EtOH X effects W/ carbamazepine, phenobarbital, phenytoin, rifampin EMS Concurrent EtOH can t adverse CNS effects OD May cause profound CNS depression symptomatic and supportive Zanamivir (Relenza) [Antiviral/Neuramidase Inhibitor] Uses Influenza A (including HlNl swine flu) B Action X Viral neuraminidase Dose Adults Feds > 7 y.2 inhal (10 mg) bid for 5 d initiate w/in 48 h of Sxs Caution [C, M] Contra Pulm Dz Disp Powder for inhal SE Bron-chospasm, HA, GI upset EMS Does not reduce risk of transmitting virus monitor for bronchospasm or other severe resp events OD May cause resp problems s5rmptomatic and supportive... 

The most common adverse effects with zaleplon are dizziness, headache, and somnolence. There is some concern about the possible occurrence of dependence, but insufficient data exist to determine whether this will be an issue with this agent. Development of tolerance does not appear to be significant. There are two drug interactions of note zaleplon plasma levels are increased when combined with cimetidine and decreased with rifampin. ... 

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