Z-discs proteins

A characteristic is the appearance of "nemaline bodies" or thickened Z-discs containing Z-disc proteins. Some hereditary diseases involve nonmuscle myosins. Among these is Usher syndrome, the commonest cause of deaf-blindness. The disease, which results from a defect in the myosin VIA gene, typically causes impairment of hearing and retinitis pigmentosa (Chapter 23).hh... 

---