Z-Ajoene

E,Z) Ajoene antithrombotic, inhibition of platelet aggregation, lipid biosynthesis inhibitor, antibacterial, antimycotic, antifungal, antimutagenic, protection of immune cells. 13,35,86.94-98,100. 

E,Z)-ajoene also showed inhibition of Paracoccidiodes bransiliensis, a dimorphic fungus pathogenic for humans. Ajoene induced alterations in phospholipid and fatty acid proportions such that phosphatydylcholine was reduced to about 18% in both morphological phases and phosphatidylethanolamine increased to 38% (Y phase) or 44% (M phase), suggesting inhibition of phosphatydylcholine synthesis. Ajoene also reduced saturated fatty acids (16 0 and 18 0) from 67 to 35% in the Y phase, with a corresponding increase in the saturated components. This effect was not seen in the M phase [98]. 

Antiproliferative activity of ajoene. Ajoene is also known to inhibit the growth of neoplastic cells. Li et al. (2002b) reported that antitumor activity of cis-Z-ajoene could be observed both in vitro and in vivo. 

Li etal. (2000) reported that Z-ajoene induced apoptosis in HL-... 

Contains 0.1-0.36% (usually ca. 0.2%) volatile oil, alliin (5-allyl-L-cysteine sulfoxide), 5-methyl-L-cysteine sulfoxide, enzymes (e.g., alliinase, peroxidase, and myrosinase), ajoenes ( ,Z-ajoene, ,Z-methylajoene, and dimethylajoene), protein (16.8%, dry weight basis), minerals, vitamins (thiamine, riboflavin, niacin, etc.), lipids, amino acids, and others (jiangsu karrer list and horhammer marsh martindale). ... 

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