Yields, therapeutic biologies

As previously indicated, some of these biological substances are now synthesized chemically, although many continue to be extracted from their native biological source material. Animals, plants and microorganisms have all yielded therapeutically important compounds, as described below. 

Despite the many decades amyl nitrite and glyceryl trinitrate have been used in therapy, it is only in recent years that the molecular mechanism of action of the nitrovasodilators has begun to be understood [3-5]. The drugs act by releasing nitric oxide (NO, a neutral radical usually written simply as NO), which produces smooth muscle relaxation in blood vessels and exhibits a range of other biological effects [6]. Thus, bioactivation to yield NO precedes the main therapeutic effect of nitrovasodilators and would justify their classifica-... 

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