Yeast invertase inhibitor

Thiosucrose (98) was also a good inhibitor for the two enzymes which act on sucrose, the levansucrase from Bacillus subtilis and the yeast invertase [19]. 

This succinyl group avoids the formation of the pyranosidic ring and acts as a spacer to conjugate the mole-cule to resins or biopolymers. The succinylated analog of sucrose 41 (R= HO2CCH2CH2CO-) is not sweet, and it is unable to inhibit invertase. It is however an inhibitor of a-glucosidase from baker s yeast. 

Invertase, fi-D-fructofuranosidase (EC 3.2.1.26) a saccharide-cleaving hydrolase from yeast, fungi and higher plants. Yeast I. is a dimeric ycoprotein (Af, 270,000), Neurospora invertase a tetrameric glycoprotein (M, 210,000, Af, of the subunit, 51,000). Aniline (fungal I.), pyridoxal (potato I.) and zinc ions (all I.) are inhibitors of I. 

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