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Y Glutamylcysteine synthase

The OSR includes induction of genes encoding Phase II biotransformation enzymes (GSTA, NQOl), enzymes involved in glutathione synthesis (y-glutamylcysteine synthase catalytic and regulatory subunits (y-GCS-c and y-GCS-r, respectively)),... [Pg.211]

Metabolism of glutathione. (1) y-Glutamylcysteine synthase (2) GSH synthase (3) glutathione peroxidase (Se-containing enzyme) 4. glutathione reductase (an FAD enzyme). [Pg.301]

GSH is synthesized in a pathway composed of two reactions. In the first reaction, y-glutamylcysteine synthase catalyzes the condensation of glutamate with cysteine (Figure 14.18). y-Glutamylcysteine, the product of this reaction, then combines with glycine to form GSH in a reaction catalyzed by glutathione synthase. [Pg.481]

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See also in sourсe #XX -- [ Pg.478 ]

See also in sourсe #XX -- [ Pg.691 ]

See also in sourсe #XX -- [ Pg.18 ]



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