Ximelagatran, hepatotoxicity

Two small molecule DTIs are argatroban (Novastan, MW 527 Da) and the oral thrombin inhibitor, ximelagatran (Exanta, MW 474 Da) Ximelagatran is an inactive pro-drug after absorption, it is metabolized to the active DTI, melagatran [MW 430 Da]. Concerns regarding hepatotoxicity have prevented (xi)melagatran... 

No evidence of hepatotoxicity was noted/observed with ximelagatran during routine preclinical assessment, or at the later extensive investigatiOTi of the potential mechanisms for the hepatic injury observed during human exposure (for a detailed description of the preclinical examinations, see later). 

Adrenaline hypertension Anticoagulants, oral skin necrosis Antituberculosis drugs hepatotoxicity Pseudoephedrine toxic epidermal necrolysis SSRIs suicidal behavior Statins acute pancreatitis Ximelagatran liver damage... 

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