Xestospongia ashmorica

Four new bioactive manzamines have been obtained from the Philippine Marine Sponge Xestospongia ashmorica [67]. Compoimd 82 is the iV-oxide derivative of manzamine A, while 84 is the 7V-oxide of 3,4-dihydromanzamine. Among these secondary metabolites, the isolation of 85 was reported, which was found to be the 6-deoxy derivative of manzamine X. 

Four New Bioactive Manzamine-Type Alkaloids from a Philippine Marine Sponge Xestospongia ashmorica. Edrada, R. A. Proksch, P. Wray, V. Witte,... 

Edrada RA, Proksch P, Wray V, Witte L, Muller WEG, Van Soest RWM. Four new bioactive manzamine-type alsaloids from the Philippine marine sponge Xestospongia ashmorica. J. Nat. Prod. 1996 59(22) 1056-1060. 

Hydroxymanzamine A was isolated from the Indonesian sponge PachypeUina sp. with moderate antitumor and anti-HSV-II activity, in 1994 ]39]. It was named as manzamine Gin some literature ]20]. 6-Hydroxymanzamine A (called manzamine Y in some references [20,41]) and 3,4-dihydromanzamine A were isolated from the Okinawan marine sponge Amphimedon sp. The Philippine sponge Xestospongia (=Acanthostrongylophora) ashmorica Hooper yielded manzamine A N-oxide, 3,4-dihydromanzamine A N-oxide, and 6-deoxymanzamine X ]10]. 

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