Xenobiotic-responsive enhancer module XREM

Figure 9.10 Illustration depicting DNA elements found in CYP3A genes and the activation of the human pregnane X receptor (PXR) by ligand (RIF) and subsequent transcriptional activation of CYP3A4 gene by the PXR/RXR heterodimer. dNR-1-3, nuclear receptors 1, 2, and 3, respectively PXR, pregnane X receptor RXR, retinoid X receptor RIF, rifampicin SRC-1, steroid receptor co-activator XREM, xenobiotic responsive enhancer module.

Figure 8.24 Activation of CYP genes by PXR and CAR. The question marks denote proteins that may have to be released from CAR In order for CAR to translocate Into the cell nucleus. XREM, xenobiotic response enhancer module PBRU, phenobarbltal-responslve enhancer unit. (Modified from Christoph Handschin and Urs A. Meyer. Pharmacol Rev55 649-673, 2003.)...

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