Xanthene oxidase

Xanthene oxidase Monamine oxidase Diamine oxidase Cytosol Mitochondria Cytosol... 

Although only a few condensed 5 6 or 5 5 aromatic pyrazole derivatives can be isolated from biological sources, the chemistry of condensed pyrazoles has received considerable interest. Condensed pyrazoles with an indene skeleton can be considered as purine analogues and, as such, are expected to have biological activity. The discovery of the xanthene oxidase inhibitory action of pyrazolo[3,4-fiT pyrimidine and the cAMP phos-phodiasterase inhibitory action of pyrazolo[l,5-a]pyrimidines has stimulated considerable interest in the synthesis of analogues of both ring systems. 

ALLOPURINOL inhibits xanthene oxidase activity, thus increasing serum azathioprine levels... 

The superoxide radical anion generated by reaction of xanthine and xanthene oxidase can be detected by ESR spin trapping technique. Besides being used for trapping the hydroxyl radical, DMPO is also used as a spin trapping agent to react with the superoxide radical anion, which forms the DMPO- OOH adduct for ESR spectroscopic measurement. 

Chinese hamster ovary-derived AS52 cells HBSS, then Ham s F12 -F5% FBS Mutagenicity gpt assay Pb (chloride) 0.1-1.0p,M for 1 hour xanthene oxidase inhibitor added At 0.8, 1.0 p,M, Pb was mutagenic inhibitor reduced mutagenesis Ariza et al. (1998)... 

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