Wynberg

T. Durst, iu E. C. Taylor and H. Wynberg, eBs., Advances in Organic Chemistry Methods and Kesults, Vol. 6, Interscience PubHshers, a division of John... 

Figures 1-3 and Tables 1-3 were originally published in the indicated volumes of the Journal of Organic Chemistry. The American Chemical Society has kindly granted permission for reproduction. The author is indebted to Professor H. Wynberg and Professor D. J. Gerritsen for encouragement to write this chapter.

Grignard reagents has been introduced by Wynberg et for the preparation of 3-substituted thiophenes. 

Through the work of especially Goldfarb et al. but also of Buu-Hoi et al., Badger et al., and Wynberg et al., the Raney nickel desulfurization of thiophenes has been developed to an important tool for the synthesis of aliphatic compounds. During the last 5 years over fifty papers have appeared describing applications of this method. 

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