Wurtz reaction, bicyclo

Wurtz reaction, bicyclo[1.1.0] butane from l-bromo-3-chlorocyclo butane, 51, 55... 

Wurtz reaction. Wiberg and Connor1 noted that lithium amalgam is far more satisfactory than either sodium or lithium for conversion of 3-bromomethyl-cyclobutyl bromide (1) into bicyclo[l.l.l]pentane (2). When sodium metal was... 

Although it s one of organic chemistry s classic reactions, the Wurtz reaction is seldom used for alkane synthesis. Alkanes are typically much more conveniently obtained from petroleum, natural gas, and the reduction of fatty acids. The Wurtz reaction is most valuable for specialized applications, particularly for closing cyclopropane rings, as in the synthesis of bicyclo[1.1.0]butane, shown below ... 

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