Withanolide novel structure

The purification, structure elucidation, and pharmacological studies on different classes of bioactive withanolides further validate the traditional uses of withanolide-producing plants to treat various ailments by local and traditional people. Diverse structural features, low toxicity, and novel and diverse mechanism of action make them suitable drug candidates for the treatment of various cancers and tumors. However, there is a need of extensive studies at the interface of chemistry and biology to fully explore the potent anticancer activity of withanolides, an essential step toward anticancer drug development with enhanced activity and lower toxicity, as compared to the available chemotherapeutic agents. 

Nittala SS, Lrolow L, Lavie D(1981) Novel occurrence of 14 J-hydroxy group on a withanolide skeleton X-Ray crystal and molecular structure of 14 J-hydroxywithanone. J Chem Soc Chem Commun 4 178... 

B 3-0-P-D-glucopyranoside, from the leaves of Physalis peruviana. Anjaneyulu et al. (1998) counted 20 isolated glycosides nested within their review. Only two further glycosides (constituents of Dunalia brachyacantha) could be integrated into the review of Veleiro et al. (2005 and references therein). However, recent structural elucidations of exactly 100 novel withanolides summarized in Table 7.10... 

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