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With difluoromethylene group, synthesis

The nucleotide analogue (38) has been prepared from the difluoromethylene phosphonate precursor (39). The presence of orthogonal protecting groups at positions 2 and 3 allows the synthesis of the difluoromethylene phosphonates of both ribonucleosides and deoxyribonucleosides. The difluoromethylene phosphonate (40) of the anti-HIV agent FTC has been prepared by glycosylation of Z>w(trimethylsilyl)-5-fluorocytosine with (41) in the presence of tin (IV)chloride. ... [Pg.178]

See other pages where With difluoromethylene group, synthesis is mentioned: [Pg.222]    [Pg.138]    [Pg.261]    [Pg.374]    [Pg.588]    [Pg.202]    [Pg.208]    [Pg.221]    [Pg.335]    [Pg.110]    [Pg.18]   
See also in sourсe #XX -- [ Pg.48 , Pg.183 ]



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Difluoromethylene

Difluoromethylene groups

Group syntheses

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