With Aldehydes and NaCN

Two regioisomers were obtained as an inseparable mixture in a 2 1 ratio Two separable regioisomers were obtained in 48 and 24 % yield, respectively 

The desired 2-aminoquinoxaline 262 could be obtained after the aerobic oxidation of R Pathway II). Under these conditions, 6-exo-dig cyclization would predominantly take place over 5-exo-tet cyclization presumably due to a better orbital orientation between HOMO and LUMO, which led to the exclusive formation of 2-aminoquinoxalines 262. Although this transformation was previously reported in literamre (Ricciardi and Joullie 1986 Hu et al. 2010), it should be noted that this transformation is operationally very simple and displayed a very broad substrate scope from aromatic aldehydes, heteroaromatic aldehydes, to more challenging aliphatic aldehydes. 

3 Condensation of o-6enzoquinone Diimines and Diimides with Various Two-Carbon Unit Suppliers 

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