Will P. falciparum Kinase Inhibitors Work as Anti-Malarial Drugs

1 Will P. falciparum Kinase Inhibitors Work as Anti-Malarial Drugs  

Whilst there is evidence of functional redundancy from research on mammalian kinases (the SRC family of kinases amongst others), there is also ample evidence from both vertebrates and non-vertebrate systems that strong phenotypes (including death) can result from the loss or inhibition of many individual kinases. It is important to note that the redundancy or otherwise of any given kinase may be hard to assess without sophisticated genetic approaches, and that the selection of one or even a few particular kinases from the P. falciparum kinome may miss the real opportunities offered by this family of signalling molecules. 

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