Wender Ring Construction Strategies

Note that in these examples the cyclopropane ring in the substrate is a sacrificial ring that acts as a surrogate for a 1,3-dipolarophile. 

Note that in these examples the cyclopropane ring in the substrate is a sacrificial ring that acts as a surrogate for a 1,3-dipolarophile. The seven-component coupling reaction is an example of a two-directional synthesis due to the high symmetry of the target product. 

---

Although Wender s synthesis was completed prior to Hudlicky s, it was published later [65]. It utilized the technique of mefa-photocycloaddition of arenes that Wender developed into a general method of synthesis for both angular and linear triquinanes. The overall strategy was centered around an intramolecular Diels-Alder cycloaddition for construction of the internal six-membered ring of the target. 

---