Weighted profile residual

In this example, lattice parameters and the zero shift correction have a substantial impact on the quality of the fit and the weighted profile residual, Rwp, decreases nearly two-fold (from 24 to 12 %), while the refinement of peak shape parameters decreases R p by only 4 %. Therefore, in this case lattice parameters should have been refined first. However, it is not always obvious which parameters are more important and should be released at a particular stage of the least squares refinement. Because of this, in complex cases a trial-and-error approach is often employed. ... 

A profile residual based on the weighted intensities of the profite at each point is defined as... 

Figure 14. Change (solid line) in apparent molecular weight distribution of water-soluble extract from a cellulase-treated ezomatsu wood residue (dotted line) at pH 4.0 brought about by the laccase HI preparation from C. versicolor, Sephadex GIO/H2O elution profiles adapted and redrawn from reference 85.

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