Wedelia asperrima

DiOH-8,3 -diOMe CivHifiOo 316 Wedelia asperrima Asteraceae Aerial 29... 

Calanasan, C.A. and MacLeod, J.K., A diterpenoid sulphate and flavonoids from Wedelia asperrima. Phytochemistry, 47, 1093, 1998. 

Glucoside 2,3, 4, 3,4-Pentahydroxychalcone okanin) C22H24O10 Wedelia asperrima Asteraceae 43... 

Wedelia asperrima is responsible for considerable losses in grazing animals, especially of sheep in Australia. The toxin responsible is wedeloside (28) with some unusual features in its structure The occurrence of an amino sugar is rare in plants the distribution of the hydroxy groups in the kauran system is quite... 

An unusual glycoside, wedeloside (96), from Wedelia asperrima (Asteraceae), inhibits mitochondrial ADP/ATP carrier protein and has the ability to protect animals against the toxic effects of aflatoxin Bi (Croteau and Johnson, 1985 Node et al., 1982). Uie diterpene forskolin (97), from Coleus barbatus and C. forskohlii (Lamiaceae), is an activator of adenylate cyclase, and is an active inhibitor of the action of brefeldin A (a fungal metabolite with pronounced effects on protein trafficking in cells) (De Sousa and Shah, 1988 Schreiber, 1992 Valdes et al., 1987 Wagner, 1988). This compound also is of interest as an antihypertensive agent (Alcaraz and Rios, 1991 Hanson, 1991). 

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