Waveform Optimization for Targeted Analyses

Targeted analyses depend not on the separation parameters of single species, but on the spreads between those for two or more species of interest. Thus, to optimize (t) for resolution of analytes X and Y, one should maximize dx-Y = M( d(JTj instead of d for X or Y alone. The dependences of optimum waveforms on Ar value (3.1.4) continue to apply if each coefficient is defined as (a x - On,Y leading to  

A prototypical isomeric separation in biological analyses is that of leucine and isoleucine amino acids. Those were (barely) resolved by FAIMS as deprotonated 

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