Water Soluble Fullerenes with Antiviral Activity

Patent Water Soluble Fullerenes with Antiviral Activity [Pg.33]

Friedman etal, US Patent 6,204,391 (March 20, 2001) Assignee The Regents of the State of California [Pg.33]

Utility Antiviral and Virucide to Inhibit Human Retroviral Replication [Pg.33]

The product from Step 1 (1.22mmol) was dissolved in 70ml dry ethyl alcohol, 3.5ml hydrazine and 7 ml acetic acid added, and the reaction refluxed 2 hours. The mixture was concentrated, the mixture purified by chromatography using neutral alumina and CH2Cl2/methyl alcohol, 98 2, and the product isolated in 66% yield. H NMR and elemental analysis data supplied. [Pg.34]

The product from Step 2 (0.086 mmol) was dissolved in 20 ml THF and one drop of a saturated solution of NaOH dissolved in ethyl alcohol and nickel peroxide (51 mg) added. The mixture was stirred over 4 A molecular sieves for 2 hours, the solution was filtered over a celite pad, and used directly for the next step. NMR, IR, and UV data supplied. [Pg.34]

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