Watanabe-Cenini-Soderberg indole synthesis

Scheme 1 Watanabe-Cenini-Soderberg Indole Synthesis...

Palladium-Catalyzed Indole Ring Synthesis Watanabe-Cenini-Soderberg... 

Several investigators have developed the reductive cyclization of o-nitrostyrenes into an efficient synthesis of indoles. Thus, research by the groups of Watanabe [480], Soderberg [481], and Cenini [482] have established this reductive Pd-catalyzed TV-het-eroannulation reaction as a viable and powerful route to simple indoles and fused indoles (411) as shown below. In addition, Soderberg has shown the application of this method to carbazolones [481d], natural p-carbolines [481e], and the carbazole alkaloid murrayaquinone A [48If]. Ohta described the related Pd-catalyzed cyclization of o-aminophenethyl alcohol to indole in 78% yield [483]. 

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See also in sourсe #XX -- [ , ]

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