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Von Frey hairs

Nerve injury, followed by pain related behaviour, is induced by loose ligation of the ischiatic nerve of one hind paw of the rat. 3-4 weeks after ligation, neuropathic pain-like behaviour is seen as increased sensitivity towards heat and pressure stimuli (hyperalgesia). Also pain reactions toward non-noxious tactile (mechanical allodynia) or cold stimuli (cold allodynia) can be observed. Mechanical allodynia is tested with von Frey hairs and cold allodynia by putting the animals on metal plate cooled to 4 °C. The number of paw liftings is counted (Bennett and Xie, Pain 1988, 33, 87-107). [Pg.579]

Chung model of neuropathic pain Nerve injury in rats is induced by a tight ligation of the root of the spinal nerve at L5-L6. Animals show hyperalgesia and allodynia similar to the Bennet model. Tactile allodynia, measured with von Frey hairs, is the most reliable parameter of pain intensity in this model (Kim and Chung, Pain 1992, 50, 355-363). [Pg.580]

Metliod AD 90% Beecher Thermal radiation of forehead Von Frey hairs on face Clinical doses Thermal radiation Foster-Carman index 1.40 Thermal radiation AD 50/100 Von Frey hairs on cornea after procaine Thermal radiation AD 50/100... [Pg.16]

A second pharmacodynamic study showed a significant reduction in pain perception of prods with von Frey hairs during the apphcation of two lidocaine formulations (microemulsion and 5% xylocaine), disconible from placebo treatment... [Pg.61]

Figure 8.1-5. (A) The shape of a single action potential is shown. (B) The top trace shows the action potentials recorded from the trigeminal ganglion. The bottom trace shows an increase in the force applied with an electronic von Frey (VF) hair on the masseter muscle until the fiber started firing action potentials. The threshold of the fiber (7.71 g) was determined by subtracting the baseline from the minimum force required to activate the fiber. Figure 8.1-5. (A) The shape of a single action potential is shown. (B) The top trace shows the action potentials recorded from the trigeminal ganglion. The bottom trace shows an increase in the force applied with an electronic von Frey (VF) hair on the masseter muscle until the fiber started firing action potentials. The threshold of the fiber (7.71 g) was determined by subtracting the baseline from the minimum force required to activate the fiber.

See other pages where Von Frey hairs is mentioned: [Pg.403]    [Pg.403]    [Pg.1186]   
See also in sourсe #XX -- [ Pg.403 ]




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