Volumetric scaleup factor

So, in the constant-density case, the inventory scaleup factor is the same as the volumetric scaleup factor. 

A volumetric scaleup by a factor of 512 is quite large, and the question arises as to whether the large vessel wiU behave as a CSTR. The concern is due to the factor of 4 increase in mixing time. Does it remain true that tmix h/i and tmix t If so, the assumption that the large vessel wiU behave as a CSTR is probably justified. The ratio of internal circulation to net throughput—which is the internal recycle ratio—scales as the inverse of the mixing time and will thus decrease by a factor of 4. The decrease may appear worrisome, but if the increase in mixing time can be tolerated, then it is likely that the decrease in internal recycle ratio is also acceptable. 

A volumetric scaleup by a factor of 512 is quite large, and the question arises as to whether the large vessel will remain well mixed on the large scale. The concern is the fact that the mixing time increases by a factor of 4. Does it remain true that [Pg.144]

The volumetric scaleup by a factor of 512 anticipates an increase in throughput by the same factor. Is this possible while maintaining reasonable product quality ... 

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