Vitamins - Vol

The synthesis of Vitamin E, that is, a-tocopherol (5,7,8-trimethyltocol) in the past has been accomplished primarily by reacting trimethylhydroquinone (TMHQ) with isophytol (3,7,ll,15-tetramethylhexadec-l-en-3-ol) or phytol (3,7,ll,15-tetramethylhexadec-2-en-l-ol) in a condensation reaction. The reaction is well known and has been practiced for many years (Stalla-Bourdillon, Ind. Chim. Belg., 35, 13 (1970) "The Vitamins" Vol. 5, pages 168-223, Academic Press, New York, 1967). 

Friedrich W (1975) In Dirscherl W (ed) Fermente, Hormone und Vitamine, vol III/2. Georg Thieme Verlag, Stuttgart, p 173... 

Ammon, R., Dirscherl, W. (eds.) Fermente - Hormone -Vitamine, Vol. III/l, Vitamine Vol. Ill 2, Vitamin B12 und verwandte Corrinoide, Thieme, Stuttgart 1974-1975 Colowick-Kaplan Methods in Enzymology, Vols. 18 A-18 C, Vitamine and Coenzymes, Aca" demic Press 1970-1971... 

G. Roller, in R. Ammon and W, Dirschel, Fermente, Hormone, Vitamins, Vol. II, Thieme, Stuttgart, i960, p. 814. 

R. Ammon and W. Dirscherl, in Fermente—Hormone—Vitamine, Vol. I Fermente, 3rd ed., Georg Thieme, Stuttgart, 1959. 

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