Vitamin P activity

It has been established that the above phenomenon is caused by the presence of certain flavonoid compounds in fruit juice that influence blood circulation, increasing the permeability and elasticity of capillaries. This action is known as vitamin P activity, but the flavonoids showing this property are not classified as vitamins, because there are several substances with this activity and no serious deficiency diseases occur if they are not consumed. There are indications that these flavonoids have a useful protective action, in particular against some respiratory diseases, but they are readily decomposed in the body and it is impossible to maintain an effective concentration in the blood. 

Arch Pharm, 270, 482 (1932) Goodwin, Pollock, Arch Biochim, Biophys, 49, 1 (1954). Has vitamin P activity. 

Demethylohesperidin, vitamin P activity, VII, 18 Deoxycholic acid, see under Desoxycholic acid... 

Phloretin, see Phloretol Phloretol, structure, VII, 17 vitamin P activity, VII, 16, 19 Phlorizin,... 

Proanthocyanidins - These are polyphenol compounds, which possess pronounced antihypoxic, antioxidant and antiinflammatory actions. They have vitamin-P activity. 

Van Caneghem, P. Influence of some hydrolysable substances with 347. vitamin P activity on the fragility of lysosomes in vitro. Biochem. Pharmacol., 21 1543-1548,1972. 

This ability to chelate heavy metal ions has been brought forward to account for some pharmacological activities shown by flavonoid compounds. Clark and Geissman showed, however, that the potentiation of effects of epinephrine by flavonoid compounds, tested upon an isolated smooth muscle preparation and attributable to the metal-chelating properties of the compounds, did not correspond with their vitamin-P activities as reported in the literature (c/. p. 275). 

In particular the vitamin P-active bioflavanoids like rutin [31, 130 etc.] and inositol have often been separated on layers, identified and determined. 

Reduction of capillary permeability and fraollltv (Vitamin P activity) Hesperldin, rutin, epicatechin, and related comoounds 3-40QQ mg/kg 46,68,90... 

Rutin (109) is known to strengthen capillary blood vessels and a French team [180, 203-206] has screened a number of amine salts of chromone-2-carboxylic acids for this type of activity (sometimes called Vitamin P activity) which was found to increase with the of the amine used. 6,8-Dimethyl-3-(2-methoxyphenyl) chromone-2-carboxylic add had no effect on capillary fragility [121]. 

Tea has been reported to have antiathero-sclerotic effects, vitamin P activities, and others. More recently reported effects include gastroprotective/antiulcer, estrogenic, immunomodulatory, antiallergic, and neuromuscular-protecting effect against botulinum and tetanus toxins. There also indications of possible benefits of tea in reducing the side effects of diabetes. ... 

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