Vitamin invention

The important biological role of the isobacteriochlorins has decisively influenced the development of synthetic approaches leading to the isobacteriochlorin class of compounds. All of the naturally occurring isobacteriochlorins contain geminally dialkylated structural parts in the saturated pyrrole rings, which require special approaches for their synthesis. Until the discovery of siroheme and sirohydrochlorin, this structural element could only be found in vitamin B,2. Using the synthetic potential, which was invented during numerous syntheses of... 

Liquid-liquid partition chromatography was invented by A. J. P. Martin and R. M. L. Synge in 1941. Martin had earlier devised a multistage solvent extraction process for the separation of vitamin E, although this work was not published. He and Synge then... 

Blot WJ, Li J-Y, Taylor PR, et al. 1993. Nutrition invention trials in Linxian, China. Supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population. J Natl Cancer Inst 85(18) 1483-1491. 

Williams (1886-1965). Williams began his studies of antiberiberi compounds in 1911 and worked for twenty-five years before discovering the correct chemical formula for the compound. Once he had that information, he was able to invent a system for producing the vitamin artificially. Today, virtually all of the vitamin Bx sold commercially is prepared artificially. 

The first surprise was provided by the fact that the two heroes of the vitamin Bi2 saga, A. Eschenmoser and R. B. Woodward, joined forces. The Harvard group dedicated itself to the more challenging A-D half, the ETH group to the B-C component. After the C-D link had been established with the aid of the sulfide-contraction invented during the course of the synthesis in Zurich, the A-B macrocyclization took place at a ligand that, with the aid of complexation with cobalt, it had been possible to fix in the quasi-cyclic conformation. 

Dakin, H. D. Am. Chem. J. 1909, 42, 477-498. Henry D. Dakin (1880-1952) was bom in London, England. During WWI, he invented his hypochlorite solution (Dakin s solution), which became a popular antiseptic for the treatment of wounds. After the Great War, he emmigrated to New York, where he investigated the B vitamins. Hocking, M. B. Bhandari, K. Shell, B. Smyth, T. A. J. Org. Chem. 1982, 47, 4208-4215. 

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