Vitamin antifungal activity

Benzimidazole is an important heterocyclic nucleus in the field of medicinal chemistry. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. The versatile nature of benzimidazole makes it a highly explored molecule in medicinal chemistry. A number of pharmacological activities are associated with benzimidazole derivatives such as anthelmintic, antiulcer, antipsychotic, proton pump inhibitor, antianxiety, anti-emetic and sedative, vasodilator, anticancer, analgesic, antihistaminic, antifungal, antiviral and antimicrobial. 

Mikhlin, E.D., V.P. Radina, A.A. Dmitrovskii et ah, 1983. Antifungal and antimicrobial activity of beta-ionone and vitamin A derivatives. Prikladnaja biochimija i mikrobiologija, 19 795-803. 

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