Vitamin antiepileptic drug-induced

Administer supplemental vitamin K during the eighth month of pregnancy to women receiving enzyme-inducing antiepileptic drugs... 

Compared with healthy controls, 51 patients with epilepsy taking a variety of antiepileptic drugs (mostly carbamaze-pine) had higher mean plasma concentrations of homocysteine (130). This effect, which could be related to reductions in the concentrations of folate and vitamin B6, was likely to be drug-induced, but a causative role of the underlying disease could not be excluded. Although homocysteine is an experimental convulsant and a risk factor for atherosclerosis, the clinical relevance of these findings is uncertain. 

Antiepileptic drugs, primarily those with inducer effects on liver enzyme activity, may cause a low folate status with risk of deficiency. Antiepileptic drugs may be associated with low levels of vitamins Bg and B2, but vitamin B12 is usually within normal range. 

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