Vital Areas in Tryptophan Molecule

Studies were conducted to determine whether other compounds would compete for 3H-tryptophan binding to rat hepatic nuclei or nuclear envelopes.173174 The data of such studies made it possible to determine which sites in L-tryptophan were vital for receptor binding. The tryptophan-binding site could be mapped by analyzing the data as to which and how test 

Competes Does Not Compete Competes Does Not Compete 

Tryptophan (trp) - indole 4- or 5-fluoro trp - 4 or 5 fluoroindole Aspartic acid - COOH Arginine - CH2CH2C=NH trp-H a-methyl trp - CH3 

7-aza trp - 7 azaindole Isoleucine - CH2CH3 Competes Does Not Compete 

Cysteine - SH Cystine - SSCH2CHCOOH Lysine - CH2CH2CH2NH2 Methionine - CH2SCH3 trp ethyl ester - OCH2CH3 naphthylamide 

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