Vinylogous Aldol Reactions in Bronsted Base Catalysis

1 Vinylogous Aldol Reactions in Bronsted Base Catalysis 

Recently, direct vinylogous aldol reactions of furanones 150 with aldehydes or ketones have been inveshgated intensively. These reactions are simple alternatives to the vinylogous Mukaiyama aldol reaction of silyloxy furans discussed in Section 

1 (Vinylogous Mukaiyama Aldol Reactions in Bronsted Acid Catalysis). 

Highly enantioselective direct vinylogous aldol reactions of dihalogenated furanones (150, R = = Cl) with aldehydes (151, R = H) are catalyzed by the 

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Br0nsted Base Catalysis Including Bijunctional Catalysis 819 Table 28.7 Direct vinylogous aldol reactions in Bronsted base catalysis. 

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