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Vicinal dialkylation nucleophiles

The general reaction sequence has been named more specifically as tandem vicinal dialkylation, nucleophilic-electrophilic carbacondensation,11 dicarbacondensation1213 or conjugate addition-enolate trapping,14 usually in reference to the fact that most of the reaction examples available create two new vicinal carbon-carbon bonds. Many noncarbon nucleophiles and electrophiles also are known, resulting... [Pg.238]

Lithium n butyl (phenylthio) cuprate has been used in nucleophilic substitution reactions of arenesulfonyl fluorides, al-lylic acetates, 9 BBN, propargyllc carbamates, and bromo-alkenes, as well as in nucleophilic additions to acetoxy-epoxides. It Is a good choice for 1,4-addItIon of an n-Bu group, having been used in 1,4 addition-elimination reactions of a-oxoketene dithloacetals and 3-halo-2-cycloalkenones, and in tandem vicinal dialkylation reactions of 5-methyleneoxa-zolones and alkynes. A typical example Is the use of the reagentin the stereospecific synthesis of (, -2-heptenoicacidfrom acetylene (eq 1). ... [Pg.325]

See other pages where Vicinal dialkylation nucleophiles is mentioned: [Pg.251]    [Pg.253]    [Pg.254]    [Pg.256]    [Pg.38]    [Pg.38]    [Pg.243]    [Pg.252]    [Pg.300]    [Pg.315]    [Pg.133]    [Pg.171]   
See also in sourсe #XX -- [ Pg.4 , Pg.253 , Pg.254 , Pg.255 , Pg.256 , Pg.257 , Pg.258 ]

See also in sourсe #XX -- [ Pg.4 , Pg.253 , Pg.254 , Pg.255 , Pg.256 , Pg.257 , Pg.258 ]



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Vicinal dialkylation

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