Vesicants toxicokinetics

Toxicokinetics of Chemical Warfare Agents Nerve Agents and Vesicants... 

This chapter provides readers with a comprehensive overview of the toxicokinetics of OP nerve agents and vesicants. 

John, H., et al. (2009) Toxicokinetics of chemical warfare agents nerve agents and vesicants. In Handbook of Toxicology of Chemical Warfare Agents, ediXed by Gupta, R.C. New York Elsevier. 

Vesicants, including sulfur mustard and lewisite, are the subject of the second main part of this chapter. Coherences of invasion and distribution are presented, and the major processes of biotransformation and elimination caused by binding to proteins [and more prominently, to deoxyribonucleic acid (DNA)] are discussed. Finally, we make some comments about current bioanalytical approaches. This chapter provides readers with a comprehensive overview of tire toxicokinetics of OP nerve agents and vesicants. 

Such exposure events that lead to poison uptake and its distribution in an organism are part of the invasion process, whereas all steps causing a decrease in poison (e.g., elimination by degradation, biotransformation, and excretion) are part of the evasion process. For a better understanding of the pathophysiology and toxicokinetics of CWAs, an overview of the routes of poison incorporation is given in the next section, with a special emphasis on OP nerve agents and vesicants. 

TOXICOKINETIC ASPECTS OF NERVE AGENTS AND VESICANTS Metabolization and elimination... 

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