Verticillium balanoides Balanol

The azepane-ring containing metabolite (—)-balanol, 349, from the fungus Verticillium balanoides <1993JA6452, 1994JAN639>, was found to be a potent ATP-competitive inhibitor of the protein kinase A (PKA) (Ki = 3.9nM)... 

Boros C, Hamilton SM, Katz B, Kulanthaivel P. Comparison of balanol from Verticillium balanoides and ophiocordin from Cordyceps ophioglossoides. J Antibiot 47 1010-1016, 1994. 

Kulanthaivel P, Hallock YF, Boros C, Hamilton SM, Janzen WP, Balias LM, Loomis CR, Jiang JB, Katz B, Steiner JR, Clardy J. Balanol a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. J Am Chem Soc 115 6452-6453, 1993. 

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