Verongula

Verongula gigantea Hyatt, Verongida, Porif. verongamine (bromotyrosine metabolite)/histamine Hj receptor antagonist Mierzwa 1994... 

Miozwa, R. King, A. Conova, M.A. Tozzi, S. Puar, M.S. Patel, M. Coval, S.J. Pomponi, S.A. (1994) Vaongamine, a novel bromotyrosine-daived histamine H4-antagonist from the marine sponge Verongula gigantea. J. Nat. Prod., 57, 175-177. 

Ciminiello P, Dell Aversano C, Fattorusso E, Magno S, Pansini M (2000) Chemistry of Verongida Sponges. 10. Secondary Metabolite Composition of the Caribbean Sponge Verongula gigantea. J Nat Prod 63 263... 

Metab. from the Caribbean sponge Verongula sp. Amorph. solid (as trifluoroacetate). CAS no. refers to trifluoroacetate. 

In an effort to compare the halogenated tyrosine derivatives from Desmospongiae Makarieva et al. (149) investigated 22 species of eleven Demospongiae families and identified 10 substances of this type in Aplysina (Verongia), Verongula, and Aiolochroia species. It has been shown that animals of the Aplysinidae family biosynthesize all three forms [(-I-), (—), (+) = racemate] of aeroplysinin-1 (233) and of an... 

Aplysinidae lanthellidae Pseudoceratinidae Aiolochroia, Aplysina, Verongula AnomoiantheKa, Hexadella, lanthella Pseudoceratina... 

Verongula gigantea 8.5 Carballeira, Shalabi, and Negron, 19S9b... 

CarbaHeira, N.M., Shalabi, F., and Negron, V. (1989b) 2-Hydroxy fatty adds from marine sponges 2. The phospholipid fatty adds of the Caribbean sponges Verongula gantea and Aplysina archeri. Lipids, 24, 229-232. 

Ciminiello, P., Dell Aversano, C., Eattorusso, E., Magno, S., and Pansini, M. (2000) Chemistry of Verongida sponges. 10. Secondary metabolite composition of the Caribbean sponge Verongula gigantea. J. Nat. Prod., 63, 263-266. 

S. J. (1994) Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gfgcmtea. J. Nat. Prod., 57,175-177. 

Monobromo- (10), bromochloro- (11), and dichloro- (12) dienones were isolated from Aplysina cavernicola (9,10). Both 10 and 11 were isolated as racemic mixtures. The dienone 13 was first obtained as a synthetic product after treatment of aeroplysinin-1 (14) with trifluoroacetic acid (11). Our group isolated 13 from the Jamaican sponge Verongula gigantea as a natural product (12). 

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