Vermisporin antimicrobial activity

Vermisporin (41) is produced by the fungus Ophiobolus vermisporis [76]. Its structure was determined by chemical degradation to the derivative (42) which was studied by X-ray crystallography and provided the absolute configuration [77]. Vermisporin exhibits antimicrobial activity towards Bacteroides spp (0.25-2 lg/ml), Clostridium perfringens (0.25-2 pg/ml) and methicillin-resistant Staphylococcus aureus (0.12-0.5 pg/ml). A metabolite of Ophiobolus rubellus produces the tetramic acid (43) that has been claimed to be an inhibitor of proline hydroxylase (IC5019pM) [78]. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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