Veratrole Friedel-Crafts acylation

A further antimony derivative, namely, bis-(para-methoxyphenyl) boryl hexachloroantimonate [prepared in situ from antimony pentachlo-ride and bis-(para-methoxyphenyl)boryl chloride] can be utilized (25% mol) in the acylation of anisole and veratrole with acetone acyl enolates in 52%-88% yield. The major advantage of the method resides in the possibility of performing Friedel-Crafts acylation at room temperature in a reaction medium that can be kept almost neutral throughout the reaction, acetone being the only co-product. 

Preparation by Friedel-Crafts acylation of veratrole with 2,3-dimethoxybenzoyl chloride in the presence of aluminium chloride at 30-40 for 16 h. The 2,3,3, 4 -tetramethoxybenzophenone formed was demethylated by heating with pyridinium chloride [281]. 

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