Vascularization, implantation signals

Neutrophils are also rapidly attracted to the site of a foreign body reaction, but likely persist in large numbers for only a few days. They generally reside within blood vessels, but in response to signals such as histamine, which increases vascular permeability, neutrophils enter the extravascular space through a process known as diapedesis. A recent study by Wozniak found that nitric oxide produced by neutrophils plays an important role in loosening of total joint implants.11... 

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