Variations Based on Isosteric Replacements

The molecular number A. Replacement of univalent FROM ISOSTERISM 

The isosterism concept atoms or groups A. Structural parameters 

The notion of pseudoatoms B. Interchange of divalent atoms B. Electronic parameters 

Erlenmeyer s expansion of and groups VI. MINOR METALLOIDS-TOXIC 

Isoserism criteria Present E. Groups with similar polar A. Carbon-silicon bioisosterism 

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CHAPTER 15 Molecular Variations Based on Isosteric Replacements... 

Wermuth, C. G. Molecular variations based on isosteric replacements. In The practice of medicinal chemistry (Wermuth, C.-G., Ed.). Academic Press London, 1996, pp. 203-237. 

Molecular Variations Based on Isosteric Replacements 199 Table 13.9 Exploration of the carboxyl isosterism possibilities in a series ofCCK antagonists ... 

Wermuth, C.G. Molecular Variations Based on Isosteric Replacements , Chapter 13 in The Practice of Medicinal Chemistry, Wermuth, C.G., Ed. (London, Academic Press, 1996). 

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